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System Labs vs Willow: Which longevity Clinic Is Better in 2026?

31 clinics scoredPrices checked weekly0 paid rankings

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Short answer

System Labs wins overall, scoring 7.3/10 vs 6.5/10. Mainly on what they can prescribe and what they disclose.

Our pick: System Labs

System Labs wins overall, scoring 7.3/10 vs 6.5/10.

System Labs · from $149/mo after an $89 first month, billed monthly

Visit →Read the System Labs review
Winner
#9 of 31

System LabsSystem Labs

7.3

Six longevity treatments, and a pricing page that gives two different answers.

from $149/mo after an $89 first month, billed monthly

Visit →
#21 of 31

WillowWillow

6.5

Names its company, 36 physicians and five pharmacies, but not the dose its $199 NAD+ vial contains or which pharmacy makes it.

from $199/mo billed monthly until cancelled

Visit →

System Labs vs Willow, side by side

FeatureSystem LabsWillow
Our score7.3/106.5/10
Starting price$149/mo after an $89 first month, billed monthly$199/mo billed monthly until cancelled
Medication typesnad-injection, nad-nasal, sermorelin-injection, sermorelin-odt, glutathione-injection, glutathione-nasalnad-injection
Best for——
Overall ranking#9#21
Real monthly cost (25%)6.56.0
Prescriber & follow-up (30%)7.07.5
What they can prescribe (20%)8.05.5
What they disclose (25%)8.06.5

Sources: System Labs pricing verified on systemlabs.com, Willow pricing verified on startwillow.com

Pros & cons

System Labs

Pros

    Cons

    • − Weaker on Real monthly cost (6.5/10)
    • − Weaker on Prescriber & follow-up (7.0/10)
    • − Weaker on What they can prescribe (8.0/10)

    Willow

    Pros

    • + Names its legal entity with a street address, 36 US-licensed physicians with individual bio pages, and all five partner pharmacies with full addresses
    • + One published monthly price that states what it includes: the vial, syringes, needles, doctor access and free shipping
    • + States plainly that compounded NAD+ is not FDA-approved, on the product page and its safety page

    Cons

    • − Weaker on What they can prescribe (5.5/10)
    • − Weaker on Real monthly cost (6.0/10)
    • − Weaker on What they disclose (6.5/10)

    The bottom line

    After scoring all 31 clinics on our 4-criterion rubric (real monthly cost, prescriber & follow-up, what they can prescribe and what they disclose), System Labs (7.3/10) comes out ahead of Willow (6.5/10). But the right choice still depends on what matters most to you.

    Choose System Labs if you want this option. From $149/mo after an $89 first month, billed monthly.

    Visit →

    Choose Willow if you want this option. From $199/mo billed monthly until cancelled.

    Visit →

    Editor's overall pick

    Not sold on either? Our highest-rated clinic overall is HealthRX (8.5/10) from $161/mo on a 1-month plan, renewing monthly. Read the review →

    Ready to start longevity care?

    Our verdict for this matchup is System Labs.

    System Labs · from $149/mo after an $89 first month, billed monthlyVisit →
    Willow · from $199/mo billed monthly until cancelledVisit →
    See full rankings

    Frequently asked questions

    Which is better, System Labs or Willow?
    System Labs scores higher overall (7.3/10 vs 6.5/10) and is our recommended pick for most people. System Labs also has the lower starting price at $149/mo after an $89 first month, billed monthly.
    How much does System Labs cost vs Willow?
    System Labs is from $149/mo after an $89 first month, billed monthly and Willow is from $199/mo billed monthly until cancelled. Both are typically cash-pay; HSA/FSA funds are often eligible. We run an automated check against each clinic's own live pricing page every week; a price left unconfirmed for 45 days shows as unverified rather than staying marked as current.
    What is the difference between System Labs and Willow?
    System Labs (7.3/10, #9 of 31) and Willow (6.5/10, #21 of 31) are scored independently across our 4 criteria: real monthly cost, prescriber & follow-up, what they can prescribe and what they disclose. See the detailed score breakdown above for the criterion-by-criterion comparison.
    Does System Labs or Willow take insurance?
    Neither System Labs nor Willow typically accepts insurance for longevity treatment. Both operate on a cash-pay model, though HSA and FSA funds are often eligible. Confirm at checkout.

    Related comparisons

    HealthRX vs System Labs→HealthRX vs Willow→MadeMed vs System Labs→MadeMed vs Willow→Ivy Rx vs System Labs→Ivy Rx vs Willow→
    Ranked by score

    Top picks

    HealthRXfrom $161/mo on a 1-month plan, renewing monthly

    Published prices on every product

    Paid link · ranks 1 of 31 on our methodology either way
    Visit →Read review
    MadeMedfrom $169/mo on a 6-month plan billed $1,014

    Best for clinical specificity

    Ranks 2 of 31 · no commercial relationship
    Read the MadeMed review
    Ivy RxIvy Rxfrom $175 with no billing period stated

    Best named clinical oversight

    Ranks 3 of 31 · no commercial relationship
    Read the Ivy Rx review

    One of these earns us a commission if you sign up. Scores are unaffected; partners are listed first at equal displayed scores. How this works →

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    How we score: every clinic is rated on five weighted criteria from documented evidence. Prices checked weekly. See each review for that clinic's own verification status. Scores are never influenced by affiliate commissions. “Visit” links may be affiliate links that support our work. Educational information only. Not medical advice.