System Labs vs He & She MD: Which longevity Clinic Is Better in 2026?
Summarize this page with
Short answer
System Labs wins overall, scoring 7.3/10 vs 6.8/10. Mainly on what they disclose and prescriber & follow-up.
System Labs wins overall, scoring 7.3/10 vs 6.8/10.
System Labs · from $149/mo after an $89 first month, billed monthly
System Labs
Six longevity treatments, and a pricing page that gives two different answers.
from $149/mo after an $89 first month, billed monthly
Visit →
He & She MD
Publishes the whole ladder and the dose. Then quotes a different annual price on its own two longevity pages.
from $229/mo on a monthly plan ($139/mo on the annual plan)
Read ReviewSystem Labs vs He & She MD, side by side
| Feature | System Labs | He & She MD |
|---|---|---|
| Our score | 7.3/10 | 6.8/10 |
| Starting price | $149/mo after an $89 first month, billed monthly | $229/mo on a monthly plan ($139/mo on the annual plan) |
| Medication types | nad-injection, nad-nasal, sermorelin-injection, sermorelin-odt, glutathione-injection, glutathione-nasal | nad-injection, nad-nasal-spray, nad-cream, sermorelin-injection, glutathione-injection, glutathione-cream |
| Best for | — | — |
| Overall ranking | #9 | #19 |
| Real monthly cost (25%) | 6.5 | 7.0 |
| Prescriber & follow-up (30%) | 7.0 | 6.0 |
| What they can prescribe (20%) | 8.0 | 8.5 |
| What they disclose (25%) | 8.0 | 6.0 |
Sources: System Labs pricing verified on systemlabs.com, He & She MD pricing verified on heandshemd.com
Pros & cons
System Labs
Pros
Cons
- − Weaker on Real monthly cost (6.5/10)
- − Weaker on Prescriber & follow-up (7.0/10)
- − Weaker on What they can prescribe (8.0/10)
He & She MD
Pros
- + Full commitment ladder published before intake, all four tiers
- + NAD+ dose published (1000 mg)
- + Six longevity products across injection, cream and nasal spray
Cons
- − Weaker on Prescriber & follow-up (6.0/10)
- − Weaker on What they disclose (6.0/10)
- − Weaker on Real monthly cost (7.0/10)
The bottom line
After scoring all 31 clinics on our 4-criterion rubric (real monthly cost, prescriber & follow-up, what they can prescribe and what they disclose), System Labs (7.3/10) comes out ahead of He & She MD (6.8/10). But the right choice still depends on what matters most to you.
Choose System Labs if you want this option. From $149/mo after an $89 first month, billed monthly.
Visit →Choose He & She MD if you want this option. From $229/mo on a monthly plan ($139/mo on the annual plan).
Read Review →Editor's overall pick
Not sold on either? Our highest-rated clinic overall is HealthRX (8.5/10) from $161/mo on a 1-month plan, renewing monthly. Read the review →
Ready to start longevity care?
Our verdict for this matchup is System Labs.
Frequently asked questions
Which is better, System Labs or He & She MD?
How much does System Labs cost vs He & She MD?
What is the difference between System Labs and He & She MD?
Does System Labs or He & She MD take insurance?
Related comparisons
Top picks
from $161/mo on a 1-month plan, renewing monthlyPublished prices on every product
from $169/mo on a 6-month plan billed $1,014Best for clinical specificity
Ivy Rxfrom $175 with no billing period statedBest named clinical oversight
One of these earns us a commission if you sign up. Scores are unaffected; partners are listed first at equal displayed scores. How this works →
We email you when a price we track changes.
No spam, no daily digest. Just the clinics you're comparing, when their verified price moves.
How we score: every clinic is rated on five weighted criteria from documented evidence. Prices checked weekly. See each review for that clinic's own verification status. Scores are never influenced by affiliate commissions. “Visit” links may be affiliate links that support our work. Educational information only. Not medical advice.