LMy Longevity Picks

System Labs vs RxSpan MD: Which longevity Clinic Is Better in 2026?

31 clinics scoredPrices checked weekly0 paid rankings

Summarize this page with

Short answer

System Labs wins overall, scoring 7.3/10 vs 6.1/10. Mainly on what they disclose and prescriber & follow-up.

Our pick: System Labs

System Labs wins overall, scoring 7.3/10 vs 6.1/10.

System Labs · from $149/mo after an $89 first month, billed monthly

Winner
#9 of 31

System LabsSystem Labs

7.3

Six longevity treatments, and a pricing page that gives two different answers.

from $149/mo after an $89 first month, billed monthly

Visit →
#26 of 31

RxSpan MD

6.1

Eight longevity treatments priced, and not one ongoing price.

from $150/mo on a prepaid 12-month plan ($249 month to month)

Visit →

System Labs vs RxSpan MD, side by side

FeatureSystem LabsRxSpan MD
Our score7.3/106.1/10
Starting price$149/mo after an $89 first month, billed monthly$150/mo on a prepaid 12-month plan ($249 month to month)
Medication typesnad-injection, nad-nasal, sermorelin-injection, sermorelin-odt, glutathione-injection, glutathione-nasalnad-injection, nad-nasal-spray, nad-tablet, sermorelin-odt, glutathione, ghk-cu, mic-b12, methylene-blue
Best for——
Overall ranking#9#26
Real monthly cost (25%)6.56.0
Prescriber & follow-up (30%)7.05.5
What they can prescribe (20%)8.08.5
What they disclose (25%)8.05.0

Sources: System Labs pricing verified on systemlabs.com, RxSpan MD pricing verified on rxspanmd.com

Pros & cons

System Labs

Pros

    Cons

    • − Weaker on Real monthly cost (6.5/10)
    • − Weaker on Prescriber & follow-up (7.0/10)
    • − Weaker on What they can prescribe (8.0/10)

    RxSpan MD

    Pros

    • + Eight longevity treatments, each with a figure attached
    • + Price is stated to include consult, medication, supplies, shipping and support
    • + Says plainly that a prescription is not guaranteed

    Cons

    • − Weaker on What they disclose (5.0/10)
    • − Weaker on Prescriber & follow-up (5.5/10)
    • − Weaker on Real monthly cost (6.0/10)

    The bottom line

    After scoring all 31 clinics on our 4-criterion rubric (real monthly cost, prescriber & follow-up, what they can prescribe and what they disclose), System Labs (7.3/10) comes out ahead of RxSpan MD (6.1/10). But the right choice still depends on what matters most to you.

    Choose System Labs if you want this option. From $149/mo after an $89 first month, billed monthly.

    Visit →

    Choose RxSpan MD if you want this option. From $150/mo on a prepaid 12-month plan ($249 month to month).

    Visit →

    Editor's overall pick

    Not sold on either? Our highest-rated clinic overall is HealthRX (8.5/10) from $161/mo on a 1-month plan, renewing monthly. Read the review →

    Ready to start longevity care?

    Our verdict for this matchup is System Labs.

    System Labs · from $149/mo after an $89 first month, billed monthlyVisit →
    RxSpan MD · from $150/mo on a prepaid 12-month plan ($249 month to month)Visit →
    See full rankings

    Frequently asked questions

    Which is better, System Labs or RxSpan MD?
    System Labs scores higher overall (7.3/10 vs 6.1/10) and is our recommended pick for most people. System Labs also has the lower starting price at $149/mo after an $89 first month, billed monthly.
    How much does System Labs cost vs RxSpan MD?
    System Labs is from $149/mo after an $89 first month, billed monthly and RxSpan MD is from $150/mo on a prepaid 12-month plan ($249 month to month). Both are typically cash-pay; HSA/FSA funds are often eligible. We run an automated check against each clinic's own live pricing page every week; a price left unconfirmed for 45 days shows as unverified rather than staying marked as current.
    What is the difference between System Labs and RxSpan MD?
    System Labs (7.3/10, #9 of 31) and RxSpan MD (6.1/10, #26 of 31) are scored independently across our 4 criteria: real monthly cost, prescriber & follow-up, what they can prescribe and what they disclose. See the detailed score breakdown above for the criterion-by-criterion comparison.
    Does System Labs or RxSpan MD take insurance?
    Neither System Labs nor RxSpan MD typically accepts insurance for longevity treatment. Both operate on a cash-pay model, though HSA and FSA funds are often eligible. Confirm at checkout.

    Related comparisons

    HealthRX vs System Labs→HealthRX vs RxSpan MD→MadeMed vs System Labs→MadeMed vs RxSpan MD→Ivy Rx vs System Labs→Ivy Rx vs RxSpan MD→
    Ranked by score

    Top picks

    HealthRXfrom $161/mo on a 1-month plan, renewing monthly

    Published prices on every product

    Paid link · ranks 1 of 31 on our methodology either way
    Visit →Read review
    MadeMedfrom $169/mo on a 6-month plan billed $1,014

    Best for clinical specificity

    Ranks 2 of 31 · no commercial relationship
    Read the MadeMed review
    Ivy RxIvy Rxfrom $175 with no billing period stated

    Best named clinical oversight

    Ranks 3 of 31 · no commercial relationship
    Read the Ivy Rx review

    One of these earns us a commission if you sign up. Scores are unaffected; partners are listed first at equal displayed scores. How this works →

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    How we score: every clinic is rated on five weighted criteria from documented evidence. Prices checked weekly. See each review for that clinic's own verification status. Scores are never influenced by affiliate commissions. “Visit” links may be affiliate links that support our work. Educational information only. Not medical advice.