The short answer: "MIC" stands for methionine, inositol and choline. A MIC or "lipo B12" shot is a compounded injection that combines those three with vitamin B12, marketed for energy and fat loss. Vitamin B12 injections are an established treatment for B12 deficiency. The MIC part is not: we searched the medical literature on 1 October 2026 and found no human trial testing MIC injections for fat loss.
What is in the shot
- Methionine, inositol and choline are often called "lipotropics", a label for nutrients involved in fat metabolism in the liver. That a nutrient plays a role in metabolism does not mean injecting extra of it burns fat, and that claim has not been tested in a published human trial we could find.
- Vitamin B12 is usually cyanocobalamin or methylcobalamin. B12 injections are FDA-approved products with a published label.
There is no FDA-approved MIC combination product. MIC shots are made by compounding pharmacies, so their exact contents and strengths vary by pharmacy.
What the vitamin B12 label says
The approved cyanocobalamin injection label describes what the B12 part is for and what it can do. It is indicated for vitamin B12 deficiencies due to malabsorption, such as pernicious anemia or after stomach surgery. It is not labeled for energy or fat loss.
On side effects, the label lists mild ones such as mild transient diarrhea, itching and a transitory rash. It also carries two serious warnings worth knowing:
- Anaphylactic shock and death have been reported after parenteral vitamin B12 administration. The label recommends a test dose for anyone suspected of being sensitive.
- Patients with early Leber's disease (hereditary optic nerve atrophy) who were treated with cyanocobalamin suffered severe and swift optic atrophy.
These are the label's serious warnings, and they are the reason a clinician should take a history before prescribing even a vitamin shot. The label does not cover methionine, inositol or choline, and we found no published safety data for injecting them in this combination.
What clinics charge, from pages we read
- Luvo Health lists Vitamin B12/MIC among its longevity treatments at $145 every four weeks, with the first four weeks at half price, $72.50 (read 28 October 2026).
- RxSpan MD lists MIC B12 at $129 "(For the first month)" (read 28 October 2026). Every figure on its longevity page carries that label, and the page prices later months only for NAD+ injection, so what MIC B12 costs from month two is not shown.
Information, not medical advice. If you are considering B12 shots for low energy, a blood test for B12 deficiency is the useful first step, and it is something a prescribing clinician can order.
