Short answer: several online clinics sell sermorelin as a dissolving tablet (often called an ODT or troche) or a nasal spray, so you avoid needles. Every published human study we found used injections. We found no published human study of oral or under-the-tongue sermorelin, and the one route that has been measured without a needle, the nose, showed low absorption. Ask the clinic what evidence its own product rests on.
Medical note: this page summarizes published research and our own reading of clinic pages. It is not medical advice.
Why the route matters
Sermorelin is a peptide: in the words of a 1999 review, "a 29 amino acid analogue of human growth hormone-releasing hormone (GHRH)." Peptides are generally broken down in the gut, which is why the approved product was an injection. The FDA-approved version, GEREF, was indicated for "the treatment of idiopathic growth hormone deficiency (GHD) in children with growth failure." It is no longer sold; FDA determined it was "not withdrawn for reasons of safety or effectiveness."
What the evidence shows about non-injected sermorelin
Nasal. A 1993 study gave the same 29 amino acid molecule by vein or by nose: "The growth hormone-releasing hormone analogue GHRH(1-29)-NH2 was administered intravenously or intranasally to 30 healthy men aged 19-43 years." Its finding on the nasal route: "Absorption of GHRH(1-29)-NH2 through the nasal mucosa was found to be low, and the bioavailability was only 3-5%." In other words, only a small fraction of a nasal dose reached the blood compared with an injection.
Oral or under the tongue. We searched PubMed on 1 October 2026 for human studies of oral, sublingual, buccal or tablet sermorelin and found none. That does not prove these products do nothing. It means there is no published human evidence for them that we could find, and clinics selling them do not cite any on the pages we read.
Questions to ask before buying a tablet or troche
- What evidence supports this form, and can you share it?
- Will you check IGF-1 to see whether it is working for me?
- Is the price per month the same as the injection, and does it rise after month one?
Who sells non-injected sermorelin, at prices we verified
From our own reading of clinic pages. "Form listed" comes from each clinic's treatment list in our database. A price is shown only where the clinic published one for that form.
| Clinic | Non-injected form listed | Price we recorded | Recorded |
|---|---|---|---|
| RxSpan MD | Sermorelin ODT (dissolving tablet) | $179, marked by the clinic "(For the first month)"; ongoing rate not shown for sermorelin | 2026-10-16 |
| System Labs | Sermorelin ODT | $79 first month, then $159, on its price block; the sermorelin FAQ on the same site quotes a higher ladder, so the page contradicts itself | 2026-10-16 |
| bmiMD | Sermorelin tablet and nasal spray | Not recorded for these forms | n/a |
| MadeMed | Oral sermorelin | Not recorded for this form; injectable sermorelin $169/mo, billed $1,014 per 6 months | 2026-09-09 |
Injectable sermorelin is more widely available and better documented. For injectable prices at every clinic we track, see sermorelin prices: entry vs. ongoing and the sermorelin page. For side effects, see sermorelin side effects.
Sources
- Wilton P, et al. Pharmacokinetics of growth hormone-releasing hormone(1-29)-NH2 and stimulation of growth hormone secretion in healthy subjects after intravenous or intranasal administration. Acta Paediatr Suppl 1993;388:10-5. PubMed 8329825. Read 1 October 2026.
- Prakash A, Goa KL. Sermorelin: a review. BioDrugs 1999;12(2):139-57. PubMed 18031173. Read 1 October 2026.
- Federal Register, 4 March 2013, document 2013-04827 (GEREF). Read 1 October 2026.
- PubMed search for oral, sublingual, buccal or tablet sermorelin in humans, run 1 October 2026: no human study found.
