The short answer: the side effects people report with NAD+ are mostly short-lived. Nausea, stomach discomfort, a fast heartbeat and a feeling of chest pressure show up when NAD+ is given into a vein quickly. For the subcutaneous injections most online clinics ship to your home, there is very little published human data at all, so nobody can give you a reliable list of how often each effect happens.
This page separates what has been measured from what is assumed, and then shows what clinics actually charge, from prices we read on their own pages.
What the human studies report
The clearest data comes from intravenous drips, not home injections. A 2026 retrospective study in Frontiers in Aging reviewed clients of a commercial wellness chain. Participants received four consecutive days of 500 mg NAD+ IV or NR IV, with 30 days follow-up. Those who received NAD+ IV reported moderate to severe gastrointestinal symptoms, increased heart rate, and chest pressure during infusions. All symptoms resolved upon infusion completion. Because of those symptoms, NAD+ drips took longer to run: on average 97 min, against 37 min for the comparison drip.
Two cautions on that study. It looked back at records rather than running a controlled trial, and every author was employed by Restore Hyperwellness, the chain whose clients were studied. It is useful as a description of what happens during a drip. It is not proof of long-term safety.
What has not been studied
A 2026 systematic review in Ageing Research Reviews searched for every human and rodent study of NAD-related compounds since 2010. The authors identified 113 eligible studies, 33 of them in humans and 80 in rodents. Their finding on injected NAD+ is blunt: no eligible outcomes trials evaluated intravenous or intramuscular NAD+ itself for anti-aging or wellness indications. Overall, they concluded, clinical effectiveness for anti-aging or wellness outcomes remains inconclusive.
In practice that means three things for someone considering home injections:
- Injection-site effects such as redness, stinging or a small lump are what you would expect from any subcutaneous shot, but we found no published trial that measured how often they occur with NAD+.
- Nausea, a fast heartbeat and chest pressure are what the drip study recorded, but a slow subcutaneous dose is not the same exposure as a fast IV infusion, so those rates do not transfer to home injections.
- Long-term effects have not been measured in any trial we could find.
If you take other medications, have heart or liver disease, or are pregnant, talk to a clinician before starting. A prescribing clinic should ask about all of these during intake.
Who prescribes it online, at prices we verified
NAD+ injections are sold by most of the clinics we track, at very different price points. A few examples, each read on the clinic's own page:
- Embody: $99 a month for NAD+ injections after a $49 first month (a sale price, read 14 October 2026), with no membership fee.
- bmiMD: $119 for one month, falling to $89 a month on its 12-month plan ($1,068 billed up front).
- System Labs: $149 a month on its monthly plan after an $89 first month, or $126 a month on a quarterly plan (read 25 October 2026); its price block shows one or the other depending on the visit, so check checkout.
- HealthRX: $161 a month on a monthly plan, $129 a month on twelve.
- Get Heally: $165 a month.
Note how the first two numbers on several of these are not the same thing: a first-month price, a prepaid term and an ongoing monthly rate are three different promises. Our NAD+ injection price comparison puts every clinic's figure in one table with its terms beside it.
This page is information, not medical advice. Side effects you notice after a dose should be reported to the clinician who prescribed it.
