NMN powder from Renue By Science costs $0.55 per gram. $54.95 for 100 g, verified from the brand's product catalog. The NAD+ injection protocols in our ranked clinic list start at $66 a month at the low end and $199 a month for most providers. That is a large gap, and it reflects something real. But not what most supplement roundups describe.
What you are buying with a supplement
Three NAD+ precursors with prices we have verified from public product pages:
| Brand | Form | Flagship SKU | Verified price | $/gram of precursor |
|---|---|---|---|---|
| Renue By Science | NMN powder | 100 g, $54.95 | Sep 2026 | $0.55 |
| Tru Niagen | NR capsules | 300 mg × 30, $49.00 | Sep 2026 | $5.44 |
| Elysium Health | NR capsules | 250 mg NR × 30, $65.00 | Sep 2026 | $8.67 |
Three additional brands in our supplement index have prices we could not verify from public pages. See our NMN vs NR cost breakdown for what blocked each one and the dose methodology behind the $/gram figures above.
What the supplement price buys: a consumer-grade capsule or powder that does not require a prescription and is not subject to FDA pre-market approval. You order it, it ships to your door, and you take it at whatever dose the label suggests or you choose. No clinician is involved.
What you are buying with a clinic protocol
Every clinic in our ranked list prescribes compounded NAD+, not a consumer supplement. Compounded formulations come from licensed 503B outsourcing facilities or 503A compounding pharmacies and require a prescription from a licensed clinician.
The 28 providers in our database cover a range of delivery methods and price points:
- Injectable NAD+. The most common delivery across our ranked set. The lowest-priced provider offering NAD+ injection in our data is Fidelity Medical Clinic at $66 a month. Most providers offering injectable protocols land in the $129–$199 a month range.
- Nasal spray, oral drops, troches. Lower-barrier delivery options offered by several providers, sometimes alongside injection.
- Combination protocols. Many clinics bundle NAD+ with sermorelin or glutathione. Pallas Health offers NAD+ injection, nasal spray, and sermorelin together starting from $189 a month; Peter MD adds a full diagnostic panel.
The monthly fee at any of these providers covers a clinician review of your intake, the compounded prescription, and ongoing refills with dose adjustments when needed. That oversight is the core of what the price premium buys.
The question the price gap cannot answer
The clinical evidence comparing injectable compounded NAD+ to oral NMN or NR supplementation at matched doses is sparse. Most published human trials on NR and NMN used oral delivery. No large randomized controlled trial has directly compared the two delivery routes in NAD+ repletion.
What the clinic price clearly does buy: physician oversight, a compounded formulation from a regulated pharmacy, and access to combination protocols that require a prescription regardless of delivery route. Sermorelin, for instance, cannot be purchased over the counter. What the price premium cannot yet buy is peer-reviewed proof that injectable delivery raises NAD+ more than oral supplementation at equivalent doses.
How to decide
If your goal is to raise NAD+ without clinical involvement and you have no conditions that warrant physician monitoring, NMN powder at $0.55 per gram is the lowest verified cost per gram in our supplement index. At the 500 mg daily dose used in several published trials, that is roughly $8–$9 a month.
If you want medical supervision, combination peptides, or injectable delivery, all of which require a prescriber, the clinic protocols in our ranked list start at $66 a month.
The decision is not supplement versus clinic. It is whether you need what only a prescriber can provide: a personalized protocol, an Rx-grade compounded formulation, and a clinician who adjusts the plan based on how you respond. If that is the route you choose, our NAD+ injection price comparison lists what every clinic we track charges.
Supplement prices sourced from brand product pages, verified September 2026. Full methodology in our NMN vs NR cost breakdown. Clinic prices from our provider database, scored on four criteria: pricing, clinical oversight, treatment options, and transparency.
